Why doesn't my serial mouse work on my PCI-bus serial port or non-standard addressed ISA-bus card?

Windows 95, 98 & ME will only work on COM1-COM4 on the standard IRQs and base addresses. This means that a mouse will only work in these base address and IRQ combinations:

COM1 (03F8) and IRQ 4
COM2 (02F8) and IRQ 3
COM3 (03E8) and IRQ 4
COM4 (02E8) and IRQ 3

So, if you are installing an ISA-bus card, you will need to set it to one of these settings for it to work. If you are installing a PCI-bus card, there isn't any way to set it to the settings Windows requires. You will just need to use an on-board serial port for your mouse instead.

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